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Hyperbaric Oxygen Therapy

Long Covid

What is Long Covid?

Long COVID, also known as post-COVID symptoms, refers to a wide range of new, returning, or lingering health problems that patients may encounter after four weeks of being infected with SARS-CoV-2.


According to the Centers for Disease Control and Prevention (CDC), even persons who have never had any symptoms might develop long COVID, which can manifest as a variety of health problems and last for a long period.


According to Dr. Sanghavi of the American Medical Association, there are three categories of long Covid.


COVID-19 causes direct cell damage as a result of the virus, which can result in long-term effects.


First Category

The first category of long covid includes those who do not fully heal and continue to have symptoms as a result of the virus’s direct cell damage.


When a person’s symptoms are linked to continuous hospitalization, they fall into the second type of long Covid-19.


Second Category

This occurs when someone remains bedridden for weeks in the hospital’s intensive care unit (ICU).


There is a weakening in the muscles and cognitive brain impairment is present.


Post-traumatic stress disorder-like conditions, also known as post-ICU care syndrome, is caused by innate psychosocial stress.


This is due to long-term hospitalization. In the third category, symptoms appear after recovery.


Covid-19 shows a variety of symptoms among patients, with some 30 year old patients dying or senior patients coming out of recovery practically unscathed.


That’s because there are a variety of patient factors at work, representing the interaction between a person’s immune system and the impact that both have on the body.


Because of the interaction between inflammatory indicators and the immune system, these “symptoms that linger” are produced after healing.


Doctors are still attempting to figure out how the immune system and inflammatory indicators interact, but there’s no doubt that those are signs of a healthy immune system or an overactive inflammatory system.


Third Category

Because Covid-19 affects all organ systems, the symptoms of long Covid are similar to Covid-19.


The fundamental systemic symptoms, according to Dr. Sanghavi, include weariness, post-COVID syndrome, and post-exercise malaise.


Patients may experience anxiety, depression, sleeplessness, and cognitive impairment, sometimes known as brain fog.


There’s also a loss of taste and smell, which can continue even after a negative test.


Symptoms of tachycardia and bradycardia include palpitation. Gastrointestinal problems and bowel troubles such as diarrhea, which can last for days, might cause a loss of appetite.


The most well-known respiratory symptoms are shortness of breath, which is caused by hypoxemia caused by lung injury.


Some patients have even had acute kidney injury, in which the kidneys do not completely heal from.


There are cases in which patients with chronic kidney disease have had to start long-term dialysis treatments after recovering from Covid.


Dr. Sanghavi also mentions patients who have hematologic concerns that end up having a blood clot.


Basically, no organ is spared when it comes to Covid-19 and there’s no way to effectively predict which organ will be affected. This is the same for long-term Covid symptoms.

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More Resources

Explore our articles, research, and downloadable booklets to learn more about HBOT.

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Hyperbaric oxygen therapy for the treatment of autoimmune diseases

While it is not considered a permanent treatment, hyperbaric oxygen therapy has been used to help alleviate autoimmune symptoms. Hyperbaric oxygen therapy involves breathing in 100% oxygen, as opposed to the 21% we absorb when we breathe naturally.


This extra oxygenation pumps oxygen into our blood plasma which improves circulation tremendously. A hyperbaric oxygen chamber uses a higher-pressure atmosphere to boost blood flow to certain body parts. This increased blood flow benefits the body in a variety of ways, as blood carries nutrients that help damaged tissues repair more quickly.


A hyperbaric oxygen chamber can be utilized for a variety of illnesses, with the benefits of hyperbaric oxygen therapy helping mend injured tissue, encouraging blood vessel formation, reducing edema, and improving general health by boosting your body’s natural defense mechanisms.


HBOT has attracted a lot of interest as a result of these applications due to its favorable results. It has been shown to lower inflammation, helps against infection, boosts the immune system, and even aids recovery from traumatic brain injury in some patients.

Related Research & Studies

Other References

Goyal A, Chonis T, Cooper JS. Hyperbaric cardiovascular effects. [Updated 2019 Jul 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482231/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522

M A, Ummer VS, Maiya AG, et al. Low level laser therapy for the patients with painful diabetic peripheral neuropathy – A systematic review, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10.1016/j.dsx.2019.07.035, (2019).

Wang EB, Kaur R, Fierro M, et al. Safety and penetration of light into the brain. Photobiomodulation in the Brain, 10.1016/B978-0-12-815305-5.00005-1, (49-66), (2019).

Mitochondrial oxidative phosphorylation defect in the heart of subjects with coronary artery disease. Ait-Aissa K, Blaszak SC, Beutner G, et al. Sci Rep. 2019 May 20; 9(1):7623. Epub 2019 May 20.

Jang S, Lewis TS, Powers C, et al. Elucidating mitochondrial electron transport chain supercomplexes in the heart during ischemia-reperfusion. Antioxid Redox Signal. 2017 Jul 1; 27(1):57-69. Epub 2016 Nov 11

Pahwa R, Jialal I. Chronic inflammation. [Updated 2019 Jun 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/

Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th edition. New York: Garland Science; 2002. Electron-Transport Chains and Their Proton Pumps. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26904/

Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31(1):27–36. doi:10.1093/carcin/bgp220

Gauldie J. Inflammation and the aging process: devil or angel. Nutr Rev. 2007 Dec; 65(12 Pt 2):S167-9.

Hillary RF, Stevenson AJ, Cox SR, et al. An epigenetic predictor of death captures multi-modal measures of brain health. Mol Psychiatry. 2019 Dec 3; Epub 2019 Dec 3.

Banszerus VL, Vetter VM, Salewsky B, et al. Exploring the relationship of relative telomere length and the epigenetic clock in the lipid cardio cohort. Int J Mol Sci. 2019 Jun 21; 20(12). Epub 2019 Jun 21.

Sullivan J, Mirbahai L, Lord JM. Major trauma and acceleration of the ageing process. Ageing Res Rev. 2018 Dec; 48:32-39. Epub 2018 Oct 11.

Mendelsohn AR, Larrick JW. Epigenetic Drift Is a Determinant of Mammalian Lifespan. Rejuvenation Res. 2017 Oct; 20(5):430-436.

Harch, PG. Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy. Med Gas Res 5, 9 (2015) doi:10.1186/s13618-015-0030-6

General Health

Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685

Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025

Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.

HBOT Mechanism

Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309

Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008

Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475

A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074

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