
Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease Treatment
Inflammatory bowel disease (IBD) is a chronic disorder that involves swelling in the digestive tract. The exact cause of inflammatory bowel disease remains unknown. Unhealthy eating habits and excessive stress were once thought to be the culprit, but these days, doctors recognize them only as aggravating factors to an already underlying condition that is yet to be fully understood.
One theory regarding the cause of IBDs is an immune system malfunction. A healthy immune system will fight off environmental triggers, such as invading viruses or bacteria, by sending immune cells to destroy the foreign organisms.
In patients with an IBD, an overactive or unnatural immune response attacks the cells in the digestive tract too, causing damage and inflammation to their own cells.
Doctors suspect that heredity plays a part in the onset of IBDs, as it has been observed to occur more commonly among people who have a family history of the disease.
However, IBDs are not well documented, so it is difficult to accurately trace the history of occurrence across generations. In any case, inflammatory bowel diseases can be debilitating and are known to cause life-threatening complications if not treated in a timely manner.
Approximately 1.6 million Americans suffer from IBD. Patients come in all ages, with 70,000 new cases reported annually.
The most common patients are of the age 15-30. In the US, an estimated 80,000 children are also affected.
The two most common types of IBDs are Ulcerative Colitis and Crohn’s Disease. Both ulcerative colitis and Crohn’s disease are known to develop symptoms such as abdominal pain, diarrhea, rectal bleeding, fatigue and weight loss.
In this blog we talk more about inflammatory bowel diseases, and how hyperbaric oxygen therapy can help manage them.
Ulcerative Colitis
Ulcerative colitis is a condition involving the occurrence of inflammation and sores (ulcers) along the outer lining of the colon (large intestine) and rectum. Complications of ulcerative colitis may include:
Toxic megacolon – the rapid widening and swelling of the colon, causing blockage.
Perforated colon – Holes in the colon itself, most commonly caused by the onset of Toxic Megacolon, but it could also occur on its own.
Severe dehydration – Lack of fluids caused by excessive diarrhea.
Crohn’s Disease
Crohn’s disease is the inflammation of the lining of our digestive tract, which very likely involves the deeper layers of the digestive tract.
Complications of Crohn’s disease may include:
Bowel obstruction – The thickening and narrowing of the bowel due to blockage. Surgery is required for removing diseased parts of the bowel.
Malnutrition – Abdominal pain, diarrhea and cramping can decrease appetite or prevent the intestine from absorbing sufficient nutrients to keep you healthy. Anemia is commonly observed in patients with Crohn’s disease due to low iron or vitamin B-12.
Fistulas – Abnormal connections between different body parts formed due to inflammation that sometimes become infected and form abscesses. The most common kind are found near or around the perineal area.
Anal fissure – A small tear in the lining of soft tissue on and around the anus and is prone to infection. It is characterized by painful bowel movements and could lead to a perianal fistula.

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Inflammatory Bowel Disease and Hyperbaric Oxygen Treatment
Patients with IBD suffer from oxygen starvation in the rectal tissues. Oxygen is a key ingredient in our body’s healing process and without it, injuries could result in swelling and tissue death.
In this way, IBDs are similar to non-healing wounds such as burns, crushing injuries, diabetic foot ulcers, skin or bone infection, skin grafts, skin flaps, gangrene, necrotizing soft tissue infection, severe anemia, sudden loss of vision or hearing, brain injuries, brain abscess, arterial gas embolism (air or gas bubbles in the blood vessels), cyanide poisoning, as well as radiation injuries from cancer treatment.
Inflammatory Bowel Disease is also the result of an abnormal immune response that is prone to triggering harmful cytokine storms.
Through hyperbaric oxygen treatment, we can enrich the plasma with a large boost of oxygen.
This has proven to help reverse tissue death, reduce inflammation, mitigate the effects of cytokine storms, and boost our tissue’s natural resistance to infection.
The unique ability of HBOT to saturate blood plasma with oxygen is proven to accelerate healing to injuries that cannot be treated through conventional means, such as those associated with inflammatory bowel disease.
There is huge potential in the use of hyperbaric oxygen therapy as a means to treat inflammatory bowel disease and help foster better, healthiers lives in those who suffer from IBD and other diseases involving non-healing wounds.
Inflammatory bowel disease is a hereditary condition where a malfunctioning immune system creates a non-healing wound in the bowel or rectum.
As with any non-healing wound, the affected tissues suffer from oxygen deprivation, resulting in abnormally slow healing, inflammation or in some cases tissue necrosis.
By increasing oxygen levels in the plasma, HBOT stimulates the body’s healing factor and helps balance the immune system by mitigating the onset of cytokine storms, an event wherein our immune system overreacts and attacks our own cells, worsening inflammation.
Hyperbaric Oxygen Therapy is a proven method of alleviating non-healing wounds. In the high- pressure, oxygen-rich environment of a hyperbaric chamber, our blood plasma is able to absorb large amounts of oxygen beyond its normal capacity.
This extra oxygen is delivered to every cell in the body, triggering the production of energy used to replenish lost tissues and fight off infection.
Hyperbaric Oxygen Therapy could potentially heal a long list of injuries and diseases such as inflammatory bowel syndrome where oxygenation and regeneration is crucial. Clinical use and better availability of hyperbaric oxygen facilities could benefit the health and well-being of 1.6 million Americans who currently suffer from inflammatory bowel disease, and help many more patients across the world.
Other References
Goyal A, Chonis T, Cooper JS. Hyperbaric cardiovascular effects. [Updated 2019 Jul 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482231/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522
M A, Ummer VS, Maiya AG, et al. Low level laser therapy for the patients with painful diabetic peripheral neuropathy – A systematic review, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 10.1016/j.dsx.2019.07.035, (2019).
Wang EB, Kaur R, Fierro M, et al. Safety and penetration of light into the brain. Photobiomodulation in the Brain, 10.1016/B978-0-12-815305-5.00005-1, (49-66), (2019).
Mitochondrial oxidative phosphorylation defect in the heart of subjects with coronary artery disease. Ait-Aissa K, Blaszak SC, Beutner G, et al. Sci Rep. 2019 May 20; 9(1):7623. Epub 2019 May 20.
Jang S, Lewis TS, Powers C, et al. Elucidating mitochondrial electron transport chain supercomplexes in the heart during ischemia-reperfusion. Antioxid Redox Signal. 2017 Jul 1; 27(1):57-69. Epub 2016 Nov 11
Pahwa R, Jialal I. Chronic inflammation. [Updated 2019 Jun 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/
Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th edition. New York: Garland Science; 2002. Electron-Transport Chains and Their Proton Pumps. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26904/
Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31(1):27–36. doi:10.1093/carcin/bgp220
Gauldie J. Inflammation and the aging process: devil or angel. Nutr Rev. 2007 Dec; 65(12 Pt 2):S167-9.
Hillary RF, Stevenson AJ, Cox SR, et al. An epigenetic predictor of death captures multi-modal measures of brain health. Mol Psychiatry. 2019 Dec 3; Epub 2019 Dec 3.
Banszerus VL, Vetter VM, Salewsky B, et al. Exploring the relationship of relative telomere length and the epigenetic clock in the lipid cardio cohort. Int J Mol Sci. 2019 Jun 21; 20(12). Epub 2019 Jun 21.
Sullivan J, Mirbahai L, Lord JM. Major trauma and acceleration of the ageing process. Ageing Res Rev. 2018 Dec; 48:32-39. Epub 2018 Oct 11.
Mendelsohn AR, Larrick JW. Epigenetic Drift Is a Determinant of Mammalian Lifespan. Rejuvenation Res. 2017 Oct; 20(5):430-436.
Harch, PG. Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy. Med Gas Res 5, 9 (2015) doi:10.1186/s13618-015-0030-6
Microbiome
Schmidt TM, Kao JY. A little O2 may go a long way in structuring the GI microbiome. Gastroenterology. 2014;147(5):956–959. doi:10.1053/j.gastro.2014.09.025
Nyabanga CT, Kulkarni G, Shen B. Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. Gastroenterology Report, Volume 5, Issue 4, November 2017, Pages 320–321, https://doi.org/10.1093/gastro/gov038
Albenberg L, Esipova TV, Judge CP, et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology, Volume 147, Issue 5,2014,Pages 1055-1063.e8,ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2014.07.020.
Crabbé A, Jensen PO, Bjarnsholt T, et al. Antimicrobial tolerance and metabolic adaptations in microbial biofilms. Trends in Microbiology. Volume 27, Issue 10, 2019, Pages 850-863, ISSN 0966-842X, https://doi.org/10.1016/j.tim.2019.05.003.
General Health
Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685
Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025
Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.
HBOT Mechanism
Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012;45(2):316–324. doi:10.4103/0970-0358.101309
Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis. Front Physiol. 2019;10:475. Published 2019 Apr 24. doi:10.3389/fphys.2019.00475
A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074
